Tabellarischer Lebenslauf

1989 bis 1996 Studium der Humanmedizin (Bonn, Philadelphia (USA))
1998 Promotion Universität Bonn (summa cum laude)
1996 bis 2003 Facharztausbildung Universitätsklinik Bonn (Innere Medizin / Kardiologie)
2004 Habilitation (Lehrbefugnis für Innere Medizin) UK Bonn
2003 bis 2008 Oberarzt (Kardiologie) Universitätsklinik Bonn (Herzbildgebung, Herzfehler (EMAH))
2008 bis 2010 Professur für Kardiovaskuläre Bildgebung Universitätsklinik Münster
2010 bis 2015 Chefarzt Kardiologie Isar Herz Zentrum München
2015 bis heute Chefarzt Peter Osypka Herzzentrum, Internistisches Klinikum München Süd
2011 bis heute Sprecher AG Echokardiographie Dt. Gesellschaft für Kardiologie
2012 bis 2016 Leiter Arbeitskreis Echokardiographie DEGUM
2014 bis heute Lehrbefugnis Technische Universität München (TUM)
2016 bis heute: Sprecher Cluster Bildgebung der DGK

Funktionen, Mitgliedschaften, Ämter

Sprecher Cluster Bildgebung der Dt. Gesellschaft für Kardiologie (DGK)
Sprecher AK Echokardiographie der Dt. Gesellschaft für Kardiologie (DGK)
Leiter des AK Echokardiographie der Dt. Gesellschaft für Ultraschall in der Medizin (DEGUM)
Senior Associate Editor der Fachzeitschrift Echocardiography
Gutachter für zahlreiche internationale Fachzeitschriften
Mitglied der European Association of Cardiovascular Imaging (EACVI)
Mitglied der American Society of Echocardiography (ASE)
Mitglied Deutsche Gesesschaft für Ultraschall in der Medizin (DEGUM)
Mitglied der Deutschen Gesellschaft für Kardiologie (DGK)

Weitere Qualifikationen
DEGUM-Seminarleiter (Stufe III) Transthorakale Echokardiographie
DEGUM-Seminarleiter (Stufe III) Transösophageale Echokardiographie
DEGUM-Seminarleiter (Stufe III) Stress-Echokardiographie

Veröffentlichungen

Percutaneous left atrial appendage occlusion: the Munich consensus document on definitions, endpoints, and data collection requirements for clinical studies.
Tzikas A, Holmes DR Jr, Gafoor S, Ruiz CE, Blomström-Lundqvist C, Diener HC, Cappato R, Kar S, Lee RJ, Byrne RA, Ibrahim R, Lakkireddy D, Soliman OI, Nabauer M, Schneider S, Brachmann J, Saver JL, Tiemann K, Sievert H, Camm AJ, Lewalter T.
Europace. 2016 Aug 18. pii: euw141. [Epub ahead of print]

Sphingosine-1-Phosphate Receptor 1 Regulates Cardiac Function by Modulating Ca2+ Sensitivity and Na+/H+ Exchange and Mediates Protection by Ischemic Preconditioning. 
Keul P, van Borren MM, Ghanem A, Müller FU, Baartscheer A, Verkerk AO, Stümpel F, Schulte JS, Hamdani N, Linke WA, van Loenen P, Matus M, Schmitz W,
Stypmann J, Tiemann K, Ravesloot JH, Alewijnse AE, Hermann S, Spijkers LJ, Hiller KH, Herr D, Heusch G, Schäfers M, Peters SL, Chun J, Levkau B
J Am Heart Assoc. 2016 May 20;5(5). pii: e003393. doi: 10.1161/JAHA.116.003393.Select item 27173870

Percutaneous left atrial appendage occlusion: the Munich consensus document on definitions, endpoints and data collection requirements for clinical studies.
Tzikas A, Holmes DR Jr, Gafoor S, Ruiz CE, Blomström-Lundqvist C, Diener HC, Cappato R, Kar S, Lee RJ, Byrne RA, Ibrahim R, Lakkireddy D, Soliman OI, Näbauer M, Schneider S, Brachman J, Saver JL, Tiemann K, Sievert H, Camm AJ, Lewalter T. EuroIntervention. 2016 May 17;12(1):103-11. doi: 10.4244/EIJV12I1A18.

Imaging reveals the connection between spontaneous coronary plaque ruptures, atherothrombosis and myocardial infarctions in HypoE/SRBI-/- mice.
Hermann S, Kuhlmann MT, Starsichova A, Eligehausen S, Schäfers KP, Stypmann J, Tiemann K, Levkau B, Schafers MA.
J Nucl Med. 2016 Apr 28. pii: jnumed.115.171132. [Epub ahead of print]

Renal Contrast-Enhanced Sonography Findings in a Model of Acute Cellular Allograft Rejection.
Grabner A, Kentrup D, Pawelski H, Mühlmeister M, Biermann C, Edemir B, Heitplatz B, Van Marck V, Bettinger T, Pavenstädt H, Schlatter E, Stypmann J, Tiemann K, Reuter S. Am J Transplant. 2016 May;16(5):1612-9. doi: 10.1111/ajt.13648. Epub 2016 Feb 26

Noninvasive Imaging of Acute Renal Allograft Rejection by Ultrasound Detection of Microbubbles Targeted to T-lymphocytes in Rats. 
Grabner A, Kentrup D, Mühlmeister M, Pawelski H, Biermann C, Bettinger T, Pavenstädt H, Schlatter E, Tiemann K, Reuter S. 
Ultraschall Med. 2016 Feb;37(1):82-91. doi: 10.1055/s-0034-1385796. Epub 2015 Apr 28.

Soluble Flt-1 links microvascular disease with heart failure in CKD.
Di Marco GS, Kentrup D, Reuter S, Mayer AB, Golle L, Tiemann K, Fobker M, Engelbertz C, Breithardt G, Brand E, Reinecke H, Pavenstädt H, Brand M.
Basic Res Cardiol. 2015 May;110(3):30. doi: 10.1007/s00395-015-0487-4. Epub 2015 Apr 21

The endocannabinoid-CB2 receptor axis protects the ischemic heart at the early stage of cardiomyopathy.
Duerr GD, Heinemann JC, Suchan G, Kolobara E, Wenzel D, Geisen C, Matthey M, Passe-Tietjen K, Mahmud W, Ghanem A, Tiemann K, Alferink J, Burgdorf S, Buchalla R, Zimmer A, Lutz B, Welz A, Fleischmann BK, Dewald O.
Basic Res Cardiol. 2014 Jul;109(4):425. doi: 10.1007/s00395-014-0425-x. Epub 2014 Jul 1.

Ultrasound-mediated gene delivery of naked plasmid DNA in skeletal muscles: a case for bolus injections.
Sanches PG, Mühlmeister M, Seip R, Kaijzel E, Löwik C, Böhmer M, Tiemann K, Grüll H.
J Control Release. 2014 Dec 10;195:130-7. doi: 10.1016/j.jconrel.2014.06.033. Epub 2014 June

Cardioprotective effects of osteopontin-1 during development of murine ischemic cardiomyopathy. 
Duerr GD, Mesenholl B, Heinemann JC, Zoerlein M, Huebener P, Schneider P, Feisst A, Ghanem A, Tiemann K, Dewald D, Welz A, Dewald O
Biomed Res Int. 2014;2014:124063. doi: 10.1155/2014/124063. Epub 2014 May 29.

Comparison of sulfur hexafluoride microbubble (SonoVue)-enhanced myocardial contrast echocardiography with gated single-photon emission computed tomography for detection of significant coronary artery disease: a large European multicenter study. 
Senior R, Moreo A, Gaibazzi N, Agati L, Tiemann K, Shivalkar B, von Bardeleben S, Galiuto L, Lardoux H, Trocino G, Carrió I, Le Guludec D, Sambuceti G, Becher H, Colonna P, Ten Cate F, Bramucci E, Cohen A, Bezante G, Aggeli C, Kasprzak JD.
J Am Coll Cardiol. 2013 Oct 8;62(15):1353-61. doi: 10.1016/j.jacc.2013.04.082. Epub 2013 Jun 13.

[Diagnostics and therapy of ischemia in chronic stable angina pectoris. Role of echocardiography].
von Bardeleben RS, Tiemann K. Herz. 2013 Jun;38(4):334-43. doi: 10.1007/s00059-013-3813-3. German. 

Real-time imaging and kinetics measurements of focused ultrasound-induced extravasation in skeletal muscle using SPECT/CT.
Sanches PG, Rossin R, Böhmer M, Tiemann K, Grüll H.
J Control Release. 2013 Jun 28;168(3):262-70. doi: 10.1016/j.jconrel.2013.03.024. Epub 2013 Apr 6.

Quantitative myocardial contrast supine bicycle stress echocardiography for detection of coronary artery disease.
Miszalski-Jamka T, Kuntz-Hehner S, Tiemann K, Karwat K, Kostkiewicz M.
Echocardiography. 2013 Apr;30(4):392-400. doi: 10.1111/echo.12064. Epub 2012 Dec 18.

Cardiomyocyte-specific deletion of survivin causes global cardiac conduction defects.
Schrickel JW, Lickfett L, Lewalter T, Tiemann K, Nickenig G, Baba H, Heusch G, Schulz R, Levkau B.
Basic Res Cardiol. 2012 Nov;107(6):299. doi: 10.1007/s00395-012-0299-8. Epub 2012 Sep 14.

4D phase contrast flow imaging for in-stent flow visualization and assessment of stent patency in peripheral vascular stents--a phantom study.
Bunck AC, Jüttner A, Kröger JR, Burg MC, Kugel H, Niederstadt T, Tiemann K, Schnackenburg B, Crelier GR, Heindel W, Maintz D.
Eur J Radiol. 2012 Sep;81(9):e929-37. doi: 10.1016/j.ejrad.2012.05.032. Epub 2012 Jul 6.

Differentiation of malignant and benign cardiac tumors using 18F-FDG PET/CT.
Rahbar K, Seifarth H, Schäfers M, Stegger L, Hoffmeier A, Spieker T, Tiemann K, Maintz D, Scheld HH, Schober O, Weckesser M.
J Nucl Med. 2012 Jun;53(6):856-63. doi: 10.2967/jnumed.111.095364. Epub 2012 May 10.

Cardiomyopathy caused by longterm treatment with chloroquine: a rare disease, or a rare diagnosis?
Tönnesmann E, Stroehmann I, Kandolf R, Wolburg H, Strach K, Musshoff F, Tiemann K, Lewalter T.
J Rheumatol. 2012 May;39(5):1099-103. doi: 10.3899/jrheum.110959. No abstract available. 

Transforming growth factor β₁ oppositely regulates the hypertrophic and contractile response to β-adrenergic stimulation in the heart.
Huntgeburth M, Tiemann K, Shahverdyan R, Schlüter KD, Schreckenberg R, Gross ML, Mödersheim S, Caglayan E, Müller-Ehmsen J, Ghanem A, Vantler M, Zimmermann WH, Böhm M, Rosenkranz S.
PLoS One. 2011;6(11):e26628. doi: 10.1371/journal.pone.0026628. Epub 2011 Nov 17.

FGF23 induces left ventricular hypertrophy.
Faul C, Amaral AP, Oskouei B, Hu MC, Sloan A, Isakova T, Gutiérrez OM, Aguillon-Prada R, Lincoln J, Hare JM, Mundel P, Morales A, Scialla J, Fischer M, Soliman EZ, Chen J, Go AS, Rosas SE, Nessel L, Townsend RR, Feldman HI, St John Sutton M, Ojo A, Gadegbeku C, Di Marco GS, Reuter S, Kentrup D, Tiemann K, Brand M, Hill JA, Moe OW, Kuro-O M, Kusek JW, Keane MG, Wolf M.
J Clin Invest. 2011 Nov;121(11):4393-408. doi: 10.1172/JCI46122. Epub 2011 Oct 10.

Exercise-induced adaptations of cardiac redox homeostasis and remodeling in heterozygous SOD2-knockout mice.
Richters L, Lange N, Renner R, Treiber N, Ghanem A, Tiemann K, Scharffetter-Kochanek K, Bloch W, Brixius K.
J Appl Physiol (1985). 2011 Nov;111(5):1431-40. doi: 10.1152/japplphysiol.01392.2010. Epub 2011 Aug 11.

Pathological 99mTc-sestamibi myocardial perfusion scintigraphy is independently associated with emerging cardiac events in elderly patients with known or suspected coronary artery disease. Bucerius J, Joe AY, Herder E, Brockmann H, Biermann K, Palmedo H, Tiemann K, Biersack HJ.
Acta Radiol. 2011 Feb 1;52(1):52-8. doi: 10.1258/ar.2010.090482.

Cardiomyoplasty improves contractile reserve after myocardial injury in mice: functional and morphological investigations with reconstructive three-dimensional echocardiography.
Ghanem A, Röll W, Bostani T, Dewald O, Fleischmann BK, Stypmann J, Nickenig G, Tiemann K.
Cell Transplant. 2011;20(10):1621-8. doi: 10.3727/096368910X564049. Epub 2011 Mar 24.

Subvalvular hypertrophic calcification of the mitral annulus: [(18)F]FDG-PET-CT, MRI, and echocardiography findings.
Persigehl T, Maintz D, Kies P, Heindel W, Schober O, Tiemann K, Rahbar K.
J Nucl Cardiol. 2011 Apr;18(2):368-70. doi: 10.1007/s12350-011-9348-1. No abstract available. 

Significant association of female gender with lower degree of pathological 99mTc-sestamibi scintigraphy results as well as higher cardiac-related deaths free survival in elderly patients. Bucerius J, Joe AY, Herder E, Brockmann H, Reinhardt MJ, Palmedo H, Tiemann K, Biersack HJ.
Med Klin (Munich). 2010 Dec;105(12):901-9. doi: 10.1007/s00063-010-1155-y. Epub 2011 Jan 16.

Cardioprotective effect of calcineurin inhibition in an animal model of renal disease.
Di Marco GS, Reuter S, Kentrup D, Ting L, Ting L, Grabner A, Jacobi AM, Pavenstädt H, Baba HA, Tiemann K, Brand M.
Eur Heart J. 2011 Aug;32(15):1935-45. doi: 10.1093/eurheartj/ehq436. Epub 2010 Dec 7.

Vascular infarction by subcutaneous application of tissue factor targeted to tumor vessels with NGR-peptides: activity and toxicity profile
Dreischalück J, Schwöppe C, Spieker T, Kessler T, Tiemann K, Liersch R, Schliemann C, Kreuter M, Kolkmeyer A, Hintelmann H, Mesters RM, Berdel WE.
Int J Oncol. 2010 Dec;37(6):1389-97. 

An ultrasound view on the substrate for incident and recurrent atrial fibrillation in heart failure patients.
Kirchhof P, Fabritz L, Tiemann K.
Eur J Heart Fail. 2010 Oct;12(10):1019-20. doi: 10.1093/eurjhf/hfq155. No abstract available. 

Three-dimensional echocardiography and 153Sm-EDTMP SPECT/CT in extensive cardiac metastases from osteosarcoma.
Tiemann K, Stypmann J, Landeta F, Wiebe S, Schäfers M, Schober O, Weckesser M, Rahbar K.
Eur J Nucl Med Mol Imaging. 2010 Dec;37(12):2406. doi: 10.1007/s00259-010-1592-0. Epub 2010 Aug 27. No abstract available. Erratum in: Eur J Nucl Med Mol Imaging. 2010 Dec;37(12):2407. Stymann, Jörg [corrected to Stypmann, Jörg]. 

Total beta-adrenoceptor deficiency results in cardiac hypotrophy and negative inotropy.
Lee S, Grafweg S, Schneider T, Jimenez M, Giacobino JP, Ghanem A, Tiemann K, Bloch W, Müller-Ehmsen J, Schwinger RH, Brixius K.
Physiol Res. 2010;59(5):679-89. Epub 2010 Apr 20.

eNOS phosphorylation and translocation are altered in male but not female mice by increased activation of the Gαq protein.
Ruiz-Holst C, Bölck B, Ghanem A, Tiemann K, Brokat S, Regitz-Zagrosek V, Bloch W, Schwinger RH, Brixius K.
Can J Physiol Pharmacol. 2010 Feb;88(2):121-9. doi: 10.1139/Y09-115.

Erratum zu: Manual zur Indikation und Durchführung der Echokardiographie.
Buck T, Breithardt OA, Faber L, Fehske W, Flachskampf FA, Franke A, Hagendorff A, Hoffmann R, Kruck I, Kücherer H, Menzel T, Pethig K, Tiemann K, Voigt JU, Weidemann F, Nixdorff U. 
Clin Res Cardiol. 2010 Jan 15. [Epub ahead of print] German. No abstract available. 

Myocardial contrast echocardiography enhances long-term prognostic value of supine bicycle stress two-dimensional echocardiography.
Miszalski-Jamka T, Kuntz-Hehner S, Schmidt H, Peter D, Miszalski-Jamka K, Hammerstingl C, Tiemann K, Ghanem A, Troatz C, Pasowicz M, Lüderitz B, Omran H.
J Am Soc Echocardiogr. 2009 Nov;22(11):1220-7. doi: 10.1016/j.echo.2009.07.020.

Targeted ultrasound-mediated delivery of nanoparticles: on the development of a new HIFU-based therapy and imaging device.
Seip R, Chin CT, Hall CS, Raju BI, Ghanem A, Tiemann K.
IEEE Trans Biomed Eng. 2010 Jan;57(1):61-70. doi: 10.1109/TBME.2009.2028874. Epub 2009 Aug 18.

Lack of gelsolin promotes perpetuation of atrial fibrillation in the mouse heart.
Schrickel JW, Fink K, Meyer R, Grohé C, Stoeckigt F, Tiemann K, Ghanem A, Lickfett L, Nickenig G, Lewalter T.
J Interv Card Electrophysiol. 2009 Oct;26(1):3-10. doi: 10.1007/s10840-009-9425-4. Epub 2009 Aug 8.

Functional impact of targeted closed-chest transplantation of bone marrow cells in rats with acute myocardial ischemia/reperfusion injury.
Ghanem A, Ziomka A, Krausgrill B, Schenk K, Troatz C, Miszalski-Jamka T, Nickenig G, Tiemann K, Müller-Ehmsen J.
Cell Transplant. 2009;18(12):1289-97. doi: 10.3727/096368909X12483162197286. Epub 2009 Aug 5.

Focused ultrasound-induced stimulation of microbubbles augments site-targeted engraftment of mesenchymal stem cells after acute myocardial infarction.
Ghanem A, Steingen C, Brenig F, Funcke F, Bai ZY, Hall C, Chin CT, Nickenig G, Bloch W, Tiemann K.
J Mol Cell Cardiol. 2009 Sep;47(3):411-8. doi: 10.1016/j.yjmcc.2009.06.008. Epub 2009 Jun 21.

Hemodynamic variables during stress testing can predict referral to early catheterization but failed to show a prognostic impact on emerging cardiac events in patients aged 70 years and older undergoing exercise (99m)Tc-sestamibi myocardial perfusion scintigraphy.
Bucerius J, Joe AY, Herder E, Brockmann H, Biermann K, Palmedo H, Tiemann K, Biersack HJ.
Int J Cardiovasc Imaging. 2009 Aug;25(6):569-79. doi: 10.1007/s10554-009-9461-2. Epub 2009 Apr 21.

Ultrasound triggered image-guided drug delivery.
Böhmer MR, Klibanov AL, Tiemann K, Hall CS, Gruell H, Steinbach OC.
Eur J Radiol. 2009 May;70(2):242-53. doi: 10.1016/j.ejrad.2009.01.051. Epub 2009 Mar 9. Review.

Normal impulse propagation in the atrioventricular conduction system of Cx30.2/Cx40 double deficient mice.
Schrickel JW, Kreuzberg MM, Ghanem A, Kim JS, Linhart M, Andrié R, Tiemann K, Nickenig G, Lewalter T, Willecke K.
J Mol Cell Cardiol. 2009 May;46(5):644-52. doi: 10.1016/j.yjmcc.2009.02.012. Epub 2009 Feb 24.

Echocardiographic assessment of global left ventricular function in mice.
Stypmann J, Engelen MA, Troatz C, Rothenburger M, Eckardt L, Tiemann K.
Lab Anim. 2009 Apr;43(2):127-37. doi: 10.1258/la.2007.06001e. Epub 2009 Feb 23. Review.

Detection of coronary artery disease with perfusion stress echocardiography using a novel ultrasound imaging agent: two Phase 3 international trials in comparison with radionuclide perfusion imaging.
Senior R, Monaghan M, Main ML, Zamorano JL, Tiemann K, Agati L, Weissman NJ, Klein AL, Marwick TH, Ahmad M, DeMaria AN, Zabalgoitia M, Becher H, Kaul S, Udelson JE, Wackers FJ, Walovitch RC, Picard MH; RAMP-1 and RAMP-2 Investigators.
Eur J Echocardiogr. 2009 Jan;10(1):26-35. doi: 10.1093/ejechocard/jen321.

Gone with the flow: percutanous retrieval of a migrated wallstent trapped in the right ventricle.
Ghanem A, Tiemann K, Nickenig G.
Eur Heart J. 2009 Mar;30(6):717. doi: 10.1093/eurheartj/ehn547. Epub 2008 Dec 5. No abstract available. 

An unusual cause for recurrent syncope in a female adult with LEOPARD syndrome.
Hammerstingl C, Ghanem A, Tiemann K.
Echocardiography. 2009 May;26(5):596-7. doi: 10.1111/j.1540-8175.2008.00828.x. Epub 2008 Dec 2.

Resolution of refractory ascites after transcoronary septal ablation for hypertrophic obstructive cardiomyopathy in a cirrhotic patient.
Höblinger A, Tiemann K, Nickenig G, Sauerbruch T, Lammert F.
Z Gastroenterol. 2008 Oct;46(10):1194-7. doi: 10.1055/s-2008-1027245. Epub 2008 Oct 20.

Impact of previous myocardial infarction on the incremental value of myocardial contrast to two-dimensional supine bicycle stress echocardiography in evaluation of coronary artery disease.
Miszalski-Jamka T, Kuntz-Hehner S, Schmidt H, Miszalski-Jamka K, Hammerstingl C, Tiemann K, Ghanem A, Troatz C, Pasowicz M, Lüderitz B, Omran H.
Int J Cardiol. 2009 Jul 24;136(1):47-55. doi: 10.1016/j.ijcard.2008.04.072.

Sex-specific pathways in early cardiac response to pressure overload in mice.
Witt H, Schubert C, Jaekel J, Fliegner D, Penkalla A, Tiemann K, Stypmann J, Roepcke S, Brokat S, Mahmoodzadeh S, Brozova E, Davidson MM, Ruiz Noppinger P, Grohé C, Regitz-Zagrosek V. J Mol Med (Berl). 2008 Sep;86(9):1013-24. doi: 10.1007/s00109-008-0385-4. Epub 2008 Jul 30.

Real-time high-resolution compound imaging allows percutaneous initiation and surveillance in an orthotopic murine pancreatic cancer model.
Ziske C, Tiemann K, Schmidt T, Nagaraj S, Märten A, Schmitz V, Clarenbach R, Sauerbruch T, Schmidt-Wolf IG.
Pancreas. 2008 Mar;36(2):146-52. doi: 10.1097/MPA.0b013e3181586cd9.

Survivin determines cardiac function by controlling total cardiomyocyte number.
Levkau B, Schäfers M, Wohlschlaeger J, von Wnuck Lipinski K, Keul P, Hermann S, Kawaguchi N, Kirchhof P, Fabritz L, Stypmann J, Stegger L, Flögel U, Schrader J, Fischer JW, Hsieh P, Ou YL, Mehrhof F, Tiemann K, Ghanem A, Matus M, Neumann J, Heusch G, Schmid KW, Conway EM, Baba HA.
Circulation. 2008 Mar 25;117(12):1583-93. doi: 10.1161/CIRCULATIONAHA.107.734160. Epub 2008 Mar 10. Erratum in: Circulation. 2008 Jun 17;117(24):e497. Fischer, Jens [corrected to Fischer, Jens W]. 

Feasibility of 18F-fluoromethylcholine PET/CT for imaging of vessel wall alterations in humans--first results.
Bucerius J, Schmaljohann J, Böhm I, Palmedo H, Guhlke S, Tiemann K, Schild HH, Biersack HJ, Manka C.
Eur J Nucl Med Mol Imaging. 2008 Apr;35(4):815-20. doi: 10.1007/s00259-007-0685-x. Epub 2008 Jan 6.

The conditional connexin43G138R mouse mutant represents a new model of hereditary oculodentodigital dysplasia in humans.
Dobrowolski R, Sasse P, Schrickel JW, Watkins M, Kim JS, Rackauskas M, Troatz C, Ghanem A, Tiemann K, Degen J, Bukauskas FF, Civitelli R, Lewalter T, Fleischmann BK, Willecke K.
Hum Mol Genet. 2008 Feb 15;17(4):539-54. Epub 2007 Nov 13.

Quantitation of myocardial borderzone using reconstructive 3-D echocardiography after chronic infarction in rats: incremental value of low-dose dobutamine.
Ghanem A, Troatz C, Elhafi N, Dewald O, Heeschen C, Nickenig G, Stypmann J, Tiemann K.
Ultrasound Med Biol. 2008 Apr;34(4):559-66. Epub 2007 Nov 8.

Detection of coronary arteries and evaluation of anastomoses with a commercially available 15-MHz, broadband, linear array transducer.
Schiller W, Rudorf H, Tiemann K, Probst C, Mellert F, Welz A.

High-resolution myocardial stress perfusion at 3 T in patients with suspected coronary artery disease.
Meyer C, Strach K, Thomas D, Litt H, Nähle CP, Tiemann K, Schwenger U, Schild HH, Sommer T.
Eur Radiol. 2008 Feb;18(2):226-33. Epub 2007 Sep 13.

Enhanced heterogeneity of myocardial conduction and severe cardiac electrical instability in annexin A7-deficient mice.
Schrickel JW, Brixius K, Herr C, Clemen CS, Sasse P, Reetz K, Grohé C, Meyer R, Tiemann K, Schröder R, Bloch W, Nickenig G, Fleischmann BK, Noegel AA, Schwinger RH, Lewalter T.
Cardiovasc Res. 2007 Nov 1;76(2):257-68. Epub 2007 Jul 6.

Toll-like receptor 4 deficiency: smaller infarcts, but no gain in function.
Kim SC, Ghanem A, Stapel H, Tiemann K, Knuefermann P, Hoeft A, Meyer R, Grohé C, Knowlton AA, Baumgarten G.
BMC Physiol. 2007 Jun 25;7:5.

Real time myocardial contrast echocardiography during supine bicycle stress and continuous infusion of contrast agent. Cutoff values for myocardial contrast replenishment discriminating abnormal myocardial perfusion. 
Miszalski-Jamka T, Kuntz-Hehner S, Schmidt H, Hammerstingl C, Tiemann K, Ghanem A, Troatz C, Lüderitz B, Omran H.
Echocardiography. 2007 Jul;24(6):638-48

Potential risks of bone marrow cell transplantation into infarcted hearts.
Breitbach M, Bostani T, Roell W, Xia Y, Dewald O, Nygren JM, Fries JW, Tiemann K, Bohlen H, Hescheler J, Welz A, Bloch W, Jacobsen SE, Fleischmann BK.
Blood. 2007 Aug 15;110(4):1362-9. Epub 2007 May 4.

Call for echo-contrast.
Tiemann K.Int J Cardiovasc Imaging. 2007 Aug;23(4):491. Epub 2007 Apr 19. No abstract available. 

Replacement of connexin43 by connexin26 in transgenic mice leads to dysfunctional reproductive organs and slowed ventricular conduction in the heart.
Winterhager E, Pielensticker N, Freyer J, Ghanem A, Schrickel JW, Kim JS, Behr R, Grümmer R, Maass K, Urschel S, Lewalter T, Tiemann K, Simoni M, Willecke K.
BMC Dev Biol. 2007 Apr 4;7:26.

Triggered replenishment imaging reduces variability of quantitative myocardial contrast echocardiography and allows assessment of myocardial blood flow reserve.
Ghanem A, DeMaria AN, Lohmaier S, El-Sayed MA, Strachan M, Sommer T, Stypmann J, Tiemann K.
Echocardiography. 2007 Feb;24(2):149-58.

Echocardiographic assessment of left ventricular mass in neonatal and adult mice: accuracy of different echocardiographic methods.
Ghanem A, Röll W, Hashemi T, Dewald O, Djoufack PC, Fink KB, Schrickel J, Lewalter T, Lüderitz B, Tiemann K.
Echocardiography. 2006 Nov;23(10):900-7.

Cardiac morphogenetic defects and conduction abnormalities in mice homozygously deficient for connexin40 and heterozygously deficient for connexin45.
Krüger O, Maxeiner S, Kim JS, van Rijen HV, de Bakker JM, Eckardt D, Tiemann K, Lewalter T, Ghanem A, Lüderitz B, Willecke K.

Persistence of iatrogenic atrial septal defect after pulmonary vein isolation--an underestimated risk?
Hammerstingl C, Lickfett L, Jeong KM, Troatz C, Wedekind JA, Tiemann K, Lüderitz B, Lewalter T.
Am Heart J. 2006 Aug;152(2):362.e1-5.

Paroxysmal atrial flutter caused by cardiac lymphoma.
Linhart M, Lickfett L, Hammerstingl C, Tiemann K, Nickenig G, Lewalter T.
Pacing Clin Electrophysiol. 2006 Jun;29(6):682-4.

Ruptured sinus of Valsalva aneurysm in two patients with subarterial ventricular septal defect.
Doll U, Herberg U, Tiemann K, Schirrmeister J, Bernhardt C, Köhler W, Schmitz C, Breuer J.
Clin Res Cardiol. 2006 Feb;95(2):127-31. Epub 2006 Jan 16.

Biliary metal stents and air embolism: a note of caution.
Rabe C, Balta Z, Wüllner U, Heller J, Hammerstingl C, Tiemann K, Sommer T, Schepke M, Fischer HP, Sauerbruch T.
Endoscopy. 2006 Jun;38(6):648-50. Epub 2006 Feb 8.

Connexin30.2 containing gap junction channels decelerate impulse propagation through the atrioventricular node.
Kreuzberg MM, Schrickel JW, Ghanem A, Kim JS, Degen J, Janssen-Bienhold U, Lewalter T, Tiemann K, Willecke K
Proc Natl Acad Sci U S A. 2006 Apr 11;103(15):5959-64. Epub 2006 Mar 29.

Age and gender related reference values for transthoracic Doppler-echocardiography in the anesthetized CD1 mouse.
Stypmann J, Engelen MA, Epping C, van Rijen HV, Milberg P, Bruch C, Breithardt G, Tiemann K, Eckardt L.
Int J Cardiovasc Imaging. 2006 Jun-Aug;22(3-4):353-62. Epub 2006 Mar 4.

Connexin31 cannot functionally replace connexin43 during cardiac morphogenesis in mice.
Zheng-Fischhöfer Q, Ghanem A, Kim JS, Kibschull M, Schwarz G, Schwab JO, Nagy J, Winterhager E, Tiemann K, Willecke K.
J Cell Sci. 2006 Feb 15;119(Pt 4):693-701. Epub 2006 Jan 31.

Open access echocardiography - guide or expense factor?
Tiemann K.

[Long-term fate of left atrial thrombi and incidence of cerebral embolism under continuous anticoagulation therapy].
Strach K, Meyer C, Hackenbroch M, Tiemann K, Haase J, Pizulli L, Omran H, Schild H, Sommer T.
Rofo. 2005 Dec;177(12):1706-12. German. 

Gold-tip electrodes--a new "deep lesion" technology for catheter ablation? In vitro comparison of a gold alloy versus platinum-iridium tip electrode ablation catheter.
Lewalter T, Bitzen A, Wurtz S, Blum R, Schlodder K, Yang A, Lickfett L, Schwab JO, Schrickel JW, Tiemann K, Linhart M, Zima E, Merkely B, Lüderitz B.
J Cardiovasc Electrophysiol. 2005 Jul;16(7):770-2.

3D motion adapted gating (3D MAG): a new navigator technique for accelerated acquisition of free breathing navigator gated 3D coronary MR-angiography.
Hackenbroch M, Nehrke K, Gieseke J, Meyer C, Tiemann K, Litt H, Dewald O, Naehle CP, Schild H, Sommer T.

[3D motion adapted gating: a new navigator technique to shorten the acquisition time for coronary MRA].
Hackenbroch M, Meyer C, Beck G, Nehrke K, Gieseke J, Yang A, Tiemann K, Schmitz C, Schild H, Sommer T.

In vitro and in vivo studies on continuous echo-contrast application strategies using SonoVue in a newly developed rotating pump setup.
Lohmaier S, Ghanem A, Veltmann C, Sommer T, Bruce M, Tiemann K.

The value of applying nitroglycerin in 3D coronary MR angiographie with real-time navigation technique].
Hackenbroch M, Meyer C, Schmiedel A, Hofer U, Flacke S, Kovács A, Tiemann K, Skowasch D, Schild H, Sommer T.
Rofo. 2004 Aug;176(8):1133-41. Effective epidermal barrier in neonatal mice lacking the C-terminal region of connexin43. 
Maass K, Ghanem A, Kim JS, Saathoff M, Urschel S, Kirfel G, Grümmer R, Kretz M, Lewalter T, Tiemann K, Winterhager E, Herzog V, Willecke K.
Mol Biol Cell. 2004 Oct;15(10):4597-608. Epub 2004 Jul 28.

Vascular flow and perfusion imaging with ultrasound contrast agents.
Bruce M, Averkiou M, Tiemann K, Lohmaier S, Powers J, Beach K.
Ultrasound Med Biol. 2004 Jun;30(6):735-43.

[Determination of the renal blood flow in macro- and microcirculation by means of pulse inversion imaging].
Schlosser T, Veltmann C, Lohmaier S, Ehlgen A, Kuntz-Hehner S, Tiemann K, Becher H.
Rofo. 2004 May;176(5):724-30. German. 

Establishment of an orthotopic tumour model for hepatocellular carcinoma and non-invasive in vivo tumour imaging by high resolution ultrasound in mice.
Schmitz V, Tirado-Ledo L, Tiemann K, Raskopf E, Heinicke T, Ziske C, González-Carmona MA, Rabe C, Wernert N, Prieto J, Qian C, Sauerbruch T, Caselmann WH. J Hepatol. 2004 May;40(5):787-91.

Transcatheter PFO closure with a prominent Eustachian valve.
Skowasch D, Peuster M, Andrié R, Tiemann K, Lüderitz B, Bauriedel G. Tumour suppression induced by the macrophage activating lipopeptide MALP-2 in an ultrasound guided pancreatic carcinoma mouse model Schneider C, Schmidt T, Ziske C, Tiemann K, Lee KM, Uhlinsky V, Behrens P, Sauerbruch T, Schmidt-Wolf IG, Mühlradt PF, Schmidt J, Märten A. Gut. 2004 Mar;53(3):355-61.

Intratumoral immunization with tumor RNA-pulsed dendritic cells confers antitumor immunity in a C57BL/6 pancreatic murine tumor model.
Schmidt T, Ziske C, Märten A, Endres S, Tiemann K, Schmitz V, Gorschlüter M, Schneider C, Sauerbruch T, Schmidt-Wolf IG.
Cancer Res. 2003 Dec 15;63(24):8962-7.

Echoscintigraphy: a new imaging modality for the reduction of color blooming and acoustic shadowing in contrast sonography.
Schlosser T, Pohl C, Kuntz-Hehner S, Omran H, Becher H, Tiemann K.
Ultrasound Med Biol. 2003 Jul;29(7):985-91.

Do we still need CK-MB in coronary artery bypass grafting surgery?
Bimmel D, Patermann B, Schlosser T, Winkler K, Tiemann K, Likungu JA, Preusse CJ, Welz A.
J Cardiovasc Surg (Torino). 2003 Apr;44(2):191-6.

Increasing myocardial contraction and blood pressure in C57BL/6 mice during early postnatal development.
Tiemann K, Weyer D, Djoufack PC, Ghanem A, Lewalter T, Dreiner U, Meyer R, Grohe C, Fink KB.
Am J Physiol Heart Circ Physiol. 2003 Feb;284(2):H464-74. Epub 2002 Oct 31.

Clinical value of myocardial contrast echocardiography in chronic coronary artery disease.
Tiemann K.
Echocardiography. 2002 Oct;19(7 Pt 2):635-9.

Induction of atrial fibrillation in mice by rapid transesophageal atrial pacing.
Schrickel JW, Bielik H, Yang A, Schimpf R, Shlevkov N, Burkhardt D, Meyer R, Grohé C, Fink K, Tiemann K, Lüderitz B, Lewalter T.
Basic Res Cardiol. 2002 Nov;97(6):452-60.

Circulating adhesion molecules in patients with internal carotid artery stenosis.
Okulla T, Gass S, Böhme K, Tiemann K, Harbrecht U, Klockgether T, Pohl C.
Cerebrovasc Dis. 2002;14(1):9-14.

On the design of a capillary flow phantom for the evaluation of ultrasound contrast agents at very low flow velocities. Veltmann C, Lohmaier S, Schlosser T, Shai S, Ehlgen A, Pohl C, Becher H, Tiemann K Ultrasound Med Biol. 2002 May;28(5):625-34.

Transesophageal contrast echocardiography distinguishes a left atrial appendage thrombus from spontaneous echo contrast.
von der Recke G, Schmidt H, Illien S, Tiemann K, Becher H, Lüderitz B, Omran H.
Echocardiography. 2002 May;19(4):343-4. No abstract available. 

Cellular cardiomyoplasty improves survival after myocardial injury.
Roell W, Lu ZJ, Bloch W, Siedner S, Tiemann K, Xia Y, Stoecker E, Fleischmann M, Bohlen H, Stehle R, Kolossov E, Brem G, Addicks K, Pfitzer G, Welz A, Hescheler J, Fleischmann BK.
Circulation. 2002 May 21;105(20):2435-41.

Ultrasonic imaging of organ perfusion with SH U 563A.
Bauer A, Becher H, Blomley M, Borges A, Cosgrove D, Leen E, Schlief R, Tiemann K.
Acad Radiol. 2002 May;9 Suppl 1:S46-51. No abstract available. 

Subendocardial steal effect seen with real-time perfusion imaging at low emission power during adenosine stress: replenishment M-mode processing allows visualization of vertical steal. Tiemann K, Ghanem A, Schlosser T, Ehlgen A, Kuntz-Hehner S, Haushofer M, Bimmel D, Borovac M, Nanda NC, Omran H, Becher H.
Echocardiography. 2001 Nov;18(8):689-94.

The impact of emission power on the destruction of echo contrast agents and on the origin of tissue harmonic signals using power pulse-inversion imaging.
Tiemann K, Veltmann C, Ghanem A, Lohmaier S, Bruce M, Kuntz-Hehner S, Pohl C, Ehlgen A, Schlosser T, Omran H, Becher H.
Ultrasound Med Biol. 2001 Nov;27(11):1525-33.

Continuous-infusion contrast-enhanced US: in vitro studies of infusion techniques with different contrast agents.
Kuntz-Hehner S, Goenechea J, Pohl C, Schlosser T, Veltmann C, Lentz C, Lohmaier S, Ehlgen A, Omran H, Becher H, Tiemann K.
Radiology. 2001 Sep;220(3):647-54.

Feasibility of the flash-replenishment concept in renal tissue: which parameters affect the assessment of the contrast replenishment?
Schlosser T, Pohl C, Veltmann C, Lohmaier S, Goenechea J, Ehlgen A, Köster J, Bimmel D, Kuntz-Hehner S, Becher H, Tiemann K.
Ultrasound Med Biol. 2001 Jul;27(7):937-44.

Blood flow assessment by ultrasound-induced destruction of echocontrast agents using harmonic power Doppler imaging: which parameters determine contrast replenishment curves? Köster J, Schlosser T, Pohl C, Lentz C, Lohmaier S, Veltmann C, Kuntz-Hehner S, Omran H, Lüderitz B, Becher H, Tiemann K.
Echocardiography. 2001 Jan;18(1):1-8.

Real-Time Contrast Echo Assessment of Myocardial Perfusion at Low Emission Power: First Experimental and Clinical Results Using Power Pulse Inversion Imaging.
Tiemann K, Lohmeier S, Kuntz S, Köster J, Pohl C, Burns P, R T, Nanda NC, Lüderitz B, Becher H.
Echocardiography. 1999 Nov;16(8):799-809.

Examination of Left External and Internal Carotid Arteries During Transesophageal Echocardiography.
Nanda NC, Biederman RW, Thakur AC, Becher H, Tiemann K, Samal AK, John AS, Nanda A, Nanda A, Kumar Narayan V V.
Echocardiography. 1998 Nov;15(8 Pt 1):755-758.

Improvement in Endocardial Border Delineation Using Tissue Harmonic Imaging.
Becher H, Tiemann K, Schlosser T, Pohl C, Nanda NC, Averkiou MA, Powers J, Lüderitz B.
Echocardiography. 1998 Jul;15(5):511-518.

Harmonic Power Doppler Contrast Echocardiography: Preliminary Clinical Results.
Becher H, Tiemann K, Schlief R, Lüderitz B, Nanda NC.
Echocardiography. 1997 Nov;14(6 Pt 1):637.

[Myocardial contrast echocardiography. Research instrument or already clinical application?].
Tiemann K, Becher H.
Z Kardiol. 2000 Oct;89(10):903-5. German. 

Stimulated acoustic emission: pseudo-Doppler shifts seen during the destruction of nonmoving microbubbles.
Tiemann K, Pohl C, Schlosser T, Goenechea J, Bruce M, Veltmann C, Kuntz S, Bangard M, Becher H.
Ultrasound Med Biol. 2000 Sep;26(7):1161-7.

[Transthoracic echocardiography in endocarditis: a comparison of conventional and harmonic echocardiography].
Schimpf R, Omran H, Becher H, Rabahieh R, Tiemann K, Jung W, Preusse CJ, Welz A, Lüderitz B.
Dtsch Med Wochenschr. 2000 Sep 15;125(37):1065-8. German. 

Incidence of left atrial thrombi in patients in sinus rhythm and with a recent neurologic deficit.
Omran H, Rang B, Schmidt H, Illien S, Schimpf R, Maccarter D, Kubini R, Von Der Recke G, Tiemann K, Becher H, Lüderitz B.
Am Heart J. 2000 Oct;140(4):658-62.

Assessment of myocardial perfusion by power contrast imaging using a new echo contrast agent.
Nanda NC, Miller A, Puri VK, Fan PH, Tiemann K, Becher H, Main J, Batra S.
Echocardiography. 2000 Jul;17(5):457-61.

Are microbubbles free flowing tracers through the Myocardium? Comparison of indicator-dilution curves obtained from dye dilution and echo contrast using harmonic power Doppler imaging. Tiemann K, Schlosser T, Pohl C, Bimmel D, Wietasch G, Hoeft A, Likungu J, Vahlhaus C, Kuntz S, Nanda NC, Becher H, Lüderitz B.
Echocardiography. 2000 Jan;17(1):17-27.

Stimulated acoustic emission detected by transcranial color doppler ultrasound : a contrast-specific phenomenon useful for the detection of cerebral tissue perfusion.
Pohl C, Tiemann K, Schlosser T, Becher H.

In vitro, animal, and human characterization of OPTISON infusions for myocardial contrast echocardiography.
Miller JJ, Tiemann K, Podell S, Doerr Stevens JK, Kuvelas T, Greener Y, Killam AL, Goenechea J, Dittrich HC, Becher H.
J Am Soc Echocardiogr. 1999 Dec;12(12):1027-34.

[Improved endocardium imaging using modified transthoracic echocardiography with the second harmonic frequency (tissue harmonic imaging)].
Becher H, Tiemann K.
Herz. 1998 Dec;23(8):467-73. Review. German. 

High-resolution emboli detection and differentiation by characteristic postembolic spectral patterns.
Ries F, Tiemann K, Pohl C, Bauer C, Mundo M, Becher H.
Stroke. 1998 Mar;29(3):668-72.

Stimulated Acoustic Emission Nonbackscatter Contrast Effect of Microbubbles Seen with Harmonic Power Doppler Imaging.
Tiemann K, Becher H, Bimmel D, Schlief R, Nanda NC.
Echocardiography. 1997 Jan;14(1):65-70.